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Wetenschappelijk onderzoek

Het Regionaal Laboratorium Medische Microbiologie en Infectiepreventie van het Jeroen Bosch Ziekenhuis voert binnen verschillende lijnen wetenschappelijk onderzoek uit. De onderzoekslijnen omvatten (chronische) Q-koorts, MRSA, respiratoire infecties, infectiemarkers en diverse casuïstiek.

 

Hieronder vindt u het overzicht van de wetenschappelijke publicaties vanuit de vakgroep Medische Microbiologie voor de jaren 2015 en 2016.

 

  1. Wielders CC, Teunis PF, Hermans MH, van der Hoek W, Schneeberger PM. Kinetics of antibody response to Coxiella burnetii infection (Q fever): Estimation of the seroresponse onset from antibody levels. Epidemics. 2015 Dec;13:37-43.
  2. Beernink TM, Wever PC, Hermans MH, Bartholomeus MG. Capnocytophaga canimorsus meningitis diagnosed by 16S rRNA PCR. Pract Neurol. 2016 Apr;16(2):136-8.
  3. Hagenaars JC, Wever PC, Vlake AW, Renders NH, van Petersen AS, Hilbink M, de Jager-Leclercq MG, Moll FL, Koning OH, Hoekstra CJ. Value of 18F-FDG PET/CT in diagnosing chronic Q fever in patients with central vascular disease. Neth J Med. 2016 Aug;74(7):301-8.
  4. van der Bij AK, Frentz D, Bonten MJ; ISIS-AR Study Group (Renders NH). Gram-positive cocci in Dutch ICUs with and without selective decontamination of the oropharyngeal and digestive tract: a retrospective database analysis. J Antimicrob Chemother. 2016 Mar;71(3):816-20. doi: 10.1093/jac/dkv396. Epub 2015 Dec 11.
  5. van der Steen M, Leenstra T, Kluytmans JA, van der Bij AK; ISIS-AR study group (Renders NH). Trends in Expanded-Spectrum Cephalosporin-Resistant Escherichia coli and Klebsiella pneumoniae among Dutch Clinical Isolates, from 2008 to 2012. PLoS One. 2015 Sep 18;10(9):e0138088. doi: 10.1371/journal.pone.0138088. eCollection 2015.
  6. Kampschreur LM, Wegdam-Blans MC, Wever PC, Renders NH, Delsing CE, Sprong T, van Kasteren ME, Bijlmer H, Notermans D, Oosterheert JJ, Stals FS, Nabuurs-Franssen MH, Bleeker-Rovers CP; Dutch Q Fever Consensus Group. Chronic Q fever diagnosis— consensus guideline versus expert opinion. Emerg Infect Dis. 2015 Jul;21(7):1183-8.
  7. Wielders CC, van Loenhout JA, Morroy G, Rietveld A, Notermans DW, Wever PC, Renders NH, Leenders AC, van der Hoek W, Schneeberger PM. Long-Term Serological Follow-Up of Acute Q-Fever Patients after a Large Epidemic. PLoS One. 2015 Jul 10;10(7):e0131848. doi: 10.1371/journal.pone.0131848. eCollection 2015.
  8. Pennings JL, Kremers MN, Hodemaekers HM, Hagenaars JC, Koning OH, Renders NH, Hermans MH, de Klerk A, Notermans DW, Wever PC, Janssen R. Dysregulation of serum gamma interferon levels in vascular chronic Q Fever patients provides insights into disease pathogenesis. Clin Vaccine Immunol. 2015 Jun;22(6):664-71. doi: 10.1128/CVI.00078-15. Epub 2015 Apr 29.
  9. Hagenaars JC, Wever PC, Shamelian SO, Van Petersen AS, Hilbink M, Renders NH, De Jager-Leclercq GL, Moll FL, Koning OH. Vascular chronic Q fever: quality of life. Epidemiol Infect. 2015 Oct;143(13):2903-9. doi: 10.1017/S0950268814003951. Epub 2015 Jan 22.
  10. Wielders CC, Hackert VH, Schimmer B, Hodemaekers HM, de Klerk A, Hoebe CJ, Schneeberger PM, van Duynhoven YT, Janssen R. Single nucleotide polymorphisms in immune response genes in acute Q fever cases with differences in self-reported symptoms. Eur J Clin Microbiol Infect Dis. 2015 May;34(5):943-50. doi: 10.1007/s10096-014-2310-9. Epub 2015 Jan 11.
  11. Wielders CC, Boerman AW, Schimmer B, van den Brom R, Notermans DW, van der Hoek W, Schneeberger PM. Persistent high IgG phase I antibody levels against Coxiella burnetii among veterinarians compared to patients previously diagnosed with acute Q fever after three years of follow-up. PLoS One. 2015 Jan 20;10(1):e0116937. doi: 10.1371/journal.pone.0116937. eCollection 2015.
  12. Van de Sande-Bruinsma N, Leverstein van Hall MA, Janssen M, Nagtzaam N, Leenders S, de Greeff SC, Schneeberger PM. Impact of livestock-associated MRSA in a hospital setting. Antimicrob Resist Infect Control. 2015 Apr 17;4:11. doi: 10.1186/s13756-015-0053-8. eCollection 2015.
  13. Morroy G, van der Hoek W, Albers J, Coutinho RA, Bleeker-Rovers CP, Schneeberger PM. Population Screening for Chronic Q-Fever Seven Years after a Major Outbreak. PLoS One. 2015 Jul 1;10(7):e0131777. doi: 10.1371/journal.pone.0131777. eCollection 2015.
  14. Morroy G, Van Der Hoek W, Nanver ZD, Schneeberger PM, Bleeker-Rovers CP, Van Der Velden J, Coutinho RA. The health status of a village population, 7 years after a major Q fever outbreak. Epidemiol Infect. 2015 Nov 12:1-10.
  15. Brandwagt DA, Herremans T, Schneeberger PM, Hackert VH, Hoebe CJ, Paget J, van der Hoek W. Waning population immunity prior to a large Q fever epidemic in the south of The Netherlands. Epidemiol Infect. 2016 Apr 14:1-7. [Epub ahead of print].
  16. Van der Wardt J, Olde Dubbelink TB, Visée HF, Schneeberger PM, Lutgens SP, van Eijk JJ. Neurologische symptomen bij hepatitis E-infectie. Ned Tijdschr Geneeskd. 2016;160(0):D107.
  17. Brooke RJ, Teunis PF, Kretzschmar ME, Wielders CC, Schneeberger PM, Waller LA. Use of a Dose-Response Model to Study Temporal Trends in Spatial Exposure to Coxiella burnetii: Analysis of a Multiyear Outbreak of Q Fever. Zoonoses Public Health. Epub 2016 Aug 23.
  18. de Lange MM, Hukkelhoven CW, Munster JM, Schneeberger PM, van der Hoek W. Nationwide registry-based ecological analysis of Q fever incidence and pregnancy outcome during an outbreak in the Netherlands.BMJ Open. 2015 Apr 10;5(4):e006821. doi: 10.1136/bmjopen-2014-006821.
  19. Kampschreur LM, Wegdam-Blans MCA, Wever PC, Renders NHM, Delsing CE, Sprong T, van Kasteren MEE, Bijlmer H, Notermans D, Oosterheert JJ, Stals FS, Nabuurs-Franssen MH, Bleeker-Rovers CP. Chronic Q fever diagnosis-consensus guideline versus expert opinion. Emerg Infect Dis. 2015 Jul;21(7):1183-8.
  20. Wever PC. Adrian Stokes en ‘trench jaundice’. Ned Tijdschr Geneeskd. 2015;159:A8648.
  21. Schoffelen T, Ammerdorffer A, Hagenaars JC, Bleeker-Rovers CP, Wegdam-Blans MC, Wever PC, Joosten LA, van der Meer JW, Sprong T, Netea MG, van Deuren M, van de Vosse E. Genetic Variation in Pattern Recognition Receptors and Adaptor Proteins Associated With Development of Chronic Q Fever. J Infect Dis. 2015 Feb 26. pii: jiv113. [Epub ahead of print].
  22. Broos PP, Hagenaars JC, Kampschreur LM, Wever PC, Bleeker-Rovers CP, Koning OH, Teijink JA, Wegdam-Blans MC. Vascular complications and surgical interventions after world's largest Q fever outbreak. J Vasc Surg. 2015 Sep 10. pii: S0741-5214(15)01484-6. doi: 10.1016/j.jvs.2015.06.217.
  23. Ammerdorffer A, Stappers MH, Oosting M, Schoffelen T, Hagenaars JC, Bleeker-Rovers CP, Wegdam-Blans MC, Wever PC, Roest HJ, van de Vosse E, Netea MG, Sprong T, Joosten LA. Genetic variation in TLR10 is not associated with chronic Q fever, despite the inhibitory effect of TLR10 on Coxiella burnetii-induced cytokines in vitro. Cytokine. 2016 Jan;77:196-202. doi: 10.1016/j.cyto.2015.09.005.
  24. Bart IY, Mourits M, van Gent R, van Leuken MH, Hilbink M, Warris A, Wever PC, de Vries E. Sputum Induction in Children Is Feasible and Useful in a Bustling General Hospital Practice. Glob Pediatr Health. 2016 Mar 4;3:2333794X16636504. doi: 10.1177/2333794X16636504. eCollection 2016.
  25. Wever PC, Hodges AJ. The First World War years of Sydney Domville Rowland: an early case of possible laboratory-acquired meningococcal disease. J R Army Med Corps. 2016 Aug;162(4):310-5. doi: 10.1136/jramc-2016-000634. Epub 2016 Apr 15.3.
  26. Wever PC, Korst MBJM, Otte M. The U.S. Army medical belt for front line first aid: a well-considered design that failed the Medical Department during the First World War. Mil Med 2016;181:1187-1194.
  27. Wever PC. No 10 Stationary Hospital and the chapel ward at Saint-Omer, France, 1914-18. BMJ 2016;355: i6509 (Christmas issue).
  28. Roerdink RL, Douw CM, Leenders AC, Dekker RS, Dietvorst M, Oosterbos CJ, Roerdink HT, Kempen RW, Bom LP. Bilateral periprosthetic joint infection with Ureaplasma urealyticum in an immunocompromised patient. Infection. 2016 Dec;44(6):807-810. Epub 2016 May 28.
  29. Dietvorst M, Roerdink R, Leenders AC, Kiel MA, Bom LP. Acute Mono-Arthritis of the Knee: A Case Report of Infection with Parvimonas Micra and Concomitant Pseudogout. J Bone Jt Infect. 2016 Oct 1;1:65-67.
  30. Leenders AC. Prevention of Surgical Site Infections: Universal Decontamination Not for All, but for a Selection of Surgical Patients. Clin Infect Dis. 2016 Jun 1;62(11):1469-70. doi: 10.1093/cid/ciw214. Epub 2016 Apr 5. No abstract available.
  31. Huijsmans CJ, van den Brule AJ, Rigter H, Poodt J, van der Linden JC, Savelkoul PH, Hilbink M, Hermans MH. Allelic imbalance at the HER2/TOP2A locus in breast cancer. Diagn Pathol. 2015 May 29;10:56. doi: 10.1186/s13000-015-0289-x.
  32. Santosaningsih D, Santoso S, Budayanti NS, Suata K, Lestari ES, Wahjono H, Djamal A, Kuntaman K, van Belkum A, Laurens M, Snijders SV, Willemse-Erix D, Goessens WH, Verbrugh HA, Severin JA. Characterisation of clinical Staphylococcus aureus isolates harbouring mecA or Panton-Valentine leukocidin genes from four tertiary care hospitals in Indonesia. Trop Med Int Health. 2016 May;21(5):610-8. doi: 10.1111/tmi.12692. Epub 2016 Mar 30.

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